Most examples of synthetic scaffolds created to mimic peptides and proteins in prior work have involved reproduction of extended chain conformation or secondary structure with peptidomimetic agents ( Pelay-Gimeno, Glas, Koch, & Grossmann, 2015). Artificial molecules that mimic proteins share this same structural hierarchy. In the hierarchy of protein structure, primary sequence encodes for formation of local secondary structure motifs, which arrange into a diverse array of complex unimolecular tertiary folding patterns and multimolecular quaternary assemblies. Mimicry of a particular protein fold provides a means for recreating the corresponding biological function. In proteins, the sequence of amino acid side chains displayed on a polypeptide backbone specifies a corresponding three-dimensional folded conformation, and this folded shape gives rise to function. Chemists have long sought to create artificial molecules with structural characteristics similar to proteins.
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